Faculty Researcher Targets Mosquitos
By Isabel Engel, NoCamels June 08, 2022
Coming Soon: Human Skin You Can Print at Home
Revolutionary 3D-printed Second Skin could provide an easier, cheaper alternative for scars and topical wounds, and eventually for skin grafts.
By Abigail Klein Leichman JUNE 10, 2022, 8:40 AM
A WORLD FIRST: Hebrew University Engineers Enhanced Cannabis Strain with 20% More THC
Findings will Help Develop New Strains for Medical Cannabis Users and Increase Crop Yields
(Jerusalem, May 31, 2022)—Throughout the world, the cannabis plant is gaining in popularity and legitimacy as a medical treatment for a broad range of illnesses. Now, researchers at the laboratory of Professor Alexander (Sasha) Vainstein at the Hebrew University of Jerusalerm (HU)’s Robert H. Smith Faculty of Agriculture, Food and Environment, in partnership with and funding from Mariana Bioscience Ltd, have successfully engineered a cannabis plant with higher levels of medically-important substances, such as THC.
The researchers successfully increased the level of THC (tetrahydrocannabinol), the main psychoactive component in cannabis, by close to 17%, and the level of CBG (cannabigerol), often referred to as the mother of all cannabinoids, by close to 25%. Further, Vainstein and his team were able to increase the ratio of terpenes, which are responsible for maximizing the euphoric effects of cannabis, by 20–30%.
The stated goal of their study was to find a way to intervene in the biochemical pathways in the cannabis plant in order to increase or decrease the production of active substances. The researchers accomplished this by manipulating a plant-based virus, that had first been neutralized so that it could not harm the plant, and then manipulating it to express the genes that influence the production of active substances in the cannabis plant. “This represents an innovative use of these tools, which were constructed using synthetic biology tools,” explained Vainstein. “Next, we developed an innovative technology based on infection with an engineered virus to facilitate chemical reactions that increase the quantities of desired substances. In collaboration with Mariana Bioscience Ltd., we examined the infected plants and found that the levels of the substances in question had indeed risen.” This is the first time that researchers have succeeded in performing such a feat with cannabis plants.
Currently, there is a great deal of research activity aimed at identifying additional substances and medical treatments that can be derived from the cannabis plant, in addition to the more than 200 active ingredients that have already been identified. Until now, there had been no way to tailor strains to produce certain cannabis substances or to alter the ratio between them. According to Vainstein, “These study results will be valuable both to industry—to increase the yield of active substances, and to medical researcher—to cultivate and develop new strains for medical cannabis users.” Vainstein added that more extensive experiments with the engineered plant are currently underway and should be available to cannabis industry leaders and medical research in the next few months.
Israeli cultured milk company Wilk (formerly Biomilk) recently nabbed a US patent for its proprietary methods and technologies to produce animal-free cultured milk and cell-based human milk, placing the company firmly on track to scale its development and enter a dairy market that was valued at over $800 billion in 2020, and an infant formula industry that is expected to reach over $100 billion by 2026.
The exclusive patent, awarded in February by the US Patent and Trademark Office, protects the company’s intellectual property and covers the methods and systems Wilk developed for the cultivation and separation of milk components from cultured cells, as the company now turns its focus on processes that increase production volume, said Wilk CEO Tomer Aizen.
For the animal-derived cultured milk, Wilk uses mammal cells “that are then grown and cultivated” in bioreactors, combined with a “secret sauce,” Aizen told The Times of Israel in a videoconference interview in February, referring to processes based on a decade of proprietary research by Dr. Nurit Argov-Argaman and Maggie Levy of the Hebrew University of Jerusalem.
Sea2Cell, which is developing cultured blue tuna, was founded in September 2021 in the Fresh Start food-tech incubator in Kiryat Shmona by Avishai Levy, Dr. Itai Tzchori, Pablo Resnik, Prof. Berta Sivan and Dr. Orna Harel. The company has raised NIS 3.5 million.
Prof. Sivan came to the fish alternatives sector from the fish industry itself. As a professor of biology at the Hebrew University Faculty of Agriculture she set up a company for accelerating the fish farming process. She was involved in another project in Africa to advance fish farming of carp in pools. But she believes wild fish should be left alone.
Prof. Sivan has gained major knowhow in isolating cells from living tissues of fish in order to raise them. She was approached by Dr. Orna Harel who for years had been thinking about developing cultured fish. They were joined by Dr. Itai Tzchori, an expert in fish stem cells and Pablo Resnik who has been involved in international trade in fish and seafood. They set up the start up in the Fresh Start incubator, a partnership of Tnuva, Tempo, OurCrowd and Finister.
While stem cells of mammals have been produced for many years, partly in research institutes, there are very few fish stem cells produced. Sea2Cell is first of all building a massive stem cell production capacity, which can be transferred under concessions for other companies to manufacture the products. The aim is blue tuna. "Prof. Sivan said, "Even if we prevent the killing of one tuna, we would have achieved something."
Tuna is overfished worldwide and attempts to raise them in captivity have failed.
N-Drip’s precise agriculture system drip-irrigates fields that were formerly flooded, addressing the world water shortage while improving outcomes.
https://www.israel21c.org/new-gravity-watering-system-saves-resources-and-raises-yields/
You are cordially invited to a series of concerts
hosted by The Faculty of Agriculture of The Hebrew University, at
The Ariovitch Auditorium
- Free Admission -
The concerts will take place once a month on Wednesday, at 13:00, and will last around 1 hour
Doubts crop up as bid to lower price of produce targets farms for reform
Plan, which would up imports and pay farmers directly rather than via tariffs, ‘risks destroying entire sector,’ warns academic as data suggests retail markups may be to blame.
Hebrew University Prof. Ayal Kimhi, vice president of the Shoresh Institution for Socioeconomic Research, said that while direct payments work, the suggested figure is “so inadequate that you risk destroying the entire farming sector.”
The number, he told The Times of Israel, was taken from the European Union, where there are large tracts of pasture land, and in no way reflects the tens of thousands of shekels poured into intensive vegetable and fruit farming. “If prices go down as a result of lowering the tariffs, people will simply abandon their farms,” he warned.
Kimhi noted that fruit and vegetable prices in Israel are still cheaper on average than in other countries in the Organization for Economic Cooperation and Development — 5% cheaper in the OECD’s most recent analysis, carried out in 2017.
In Europe, the process of moving to direct payments to farmers took two decades. “Lowering import tariffs is right but you need to do it slowly, carefully, and to stop each time and review the result. Five years is too fast,” said Kimhi.
Faculty graduates create "Hop A Tour" - where visitors can find live virtual tours led by world-class tour guides.
FACING CLIMATE CHANGE TOGETHER:
UAE Minister of Food and Water Security
Meets Agtech and Foodtech Experts at Faculty of Agriculture
Plant-based meat substitute producer, SavorEat, has announced that it is opening up a subsidiary to tackle another protein in the plant-based battle for our meals. EGG’N’UP will have a crack at developing food products based on natural egg substitutes, designed to replace eggs without impeding on their original taste or nutritional values. ..
https://www.calcalistech.com/ctech/articles/0,7340,L-3906977,00.html
Ever Wonder What A Potato Feels…?
Hebrew U. Develops Bio-Sensor to Detect Early Signs of Plant Stress
and Prevent Crop Failures from Worldwide Climate Changes
In an effort to increase agricultural productivity and limit waste, a team of researchers from the Hebrew University of Jerusalem (HU)’s Robert H. Smith Faculty of Agriculture, Food and Environment developed a method to detect signs of stress before the plant is damaged.
PNAS Journal Club: In the 1930s, scientists discovered a heavier form of water. So-called “heavy water” (D2O) weighs more because the nucleus of each of its two hydrogen atoms contains not just a proton but a neutron as well. Known as deuterium, heavy hydrogen causes subtle differences in heavy water—from small increases in boiling and freezing points to a roughly 10% increase in density.
Now, an international team of researchers has confirmed another difference long rumored to be true: Heavy water tastes sweet. “It’s a very gentle sweetness,” says study author Masha Niv, a taste scientist at the Hebrew University of Jerusalem. “It’s not like Sweet’n Low.”
Heavy water won’t work as a sweetener. Indeed, in large quantities, it’s lethal. But the work, recently reported in Communications Biology, could inspire a deeper understanding of how the sweet taste receptor works.
Heavy water’s flavor has rarely been formally tested as part of an experiment. Harold Urey, who discovered deuterium, tasted heavy water in 1935 and reported with a colleague in Science that it was no different than regular water. And a more recent study relied on human sensory studies alone to investigate. But anecdotally, some chemists have reported that heavy water tastes sweet—including Niv’s coauthors, chemists Pavel Jungwirth and Phil Mason of the Czech Academy of Sciences in Prague. So they and collaborators decided to put that sweetness to the test.