plant science and genetics

yotam-zait

Dr. Yotam Zait

Senior Lecturer (Assistant Professor)
Yotam.Zait@mail.huji.ac.il
Photosynthesis and water use efficiency improvement in crops, optimizing mesophyll conductance to CO2, guard cell physiology

Cannabis Strain with 20% More THC

31 May, 2022

A WORLD FIRST: Hebrew University Engineers Enhanced Cannabis Strain with 20% More THC

Findings will Help Develop New Strains for Medical Cannabis Users and Increase Crop Yields

(Jerusalem, May 31, 2022)—Throughout the world, the cannabis plant is gaining in popularity and legitimacy as a medical treatment for a broad range of illnesses. Now, researchers at the laboratory of Professor Alexander (Sasha) Vainstein at the Hebrew University of Jerusalerm (HU)’s Robert H. Smith Faculty of Agriculture, Food and Environment, in partnership with and funding from Mariana Bioscience Ltd, have successfully engineered a cannabis plant with higher levels of medically-important substances, such as THC.

The researchers successfully increased the level of THC (tetrahydrocannabinol), the main psychoactive component in cannabis, by close to 17%, and the level of CBG (cannabigerol), often referred to as the mother of all cannabinoids, by close to 25%.  Further, Vainstein and his team were able to increase the ratio of terpenes, which are responsible for maximizing the euphoric effects of cannabis, by 20–30%.

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The stated goal of their study was to find a way to intervene in the biochemical pathways in the cannabis plant in order to increase or decrease the production of active substances. The researchers accomplished this by manipulating a plant-based virus, that had first been neutralized so that it could not harm the plant, and then manipulating it to express the genes that influence the production of active substances in the cannabis plant. “This represents an innovative use of these tools, which were constructed using synthetic biology tools,” explained Vainstein. “Next, we developed an innovative technology based on infection with an engineered virus to facilitate chemical reactions that increase the quantities of desired substances.  In collaboration with Mariana Bioscience Ltd., we examined the infected plants and found that the levels of the substances in question had indeed risen.” This is the first time that researchers have succeeded in performing such a feat with cannabis plants.

Currently, there is a great deal of research activity aimed at identifying additional substances and medical treatments that can be derived from the cannabis plant, in addition to the more than 200 active ingredients that have already been identified. Until now, there had been no way to tailor strains to produce certain cannabis substances or to alter the ratio between them.  According to Vainstein, “These study results will be valuable both to industry—to increase the yield of active substances, and to medical researcher—to cultivate and develop new strains for medical cannabis users.” Vainstein added that more extensive experiments with the engineered plant are currently underway and should be available to cannabis industry leaders and medical research in the next few months.

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Eli Zamski

Prof. Eli Zamski

Emeritus
Tel: +972-(0)8-9481317 | Fax: +972-(0)8-9467763
eliezer.zamski@mail.huji.ac.il
Peanut crop improvement, Sugar metabolism in melon fruits, Petunia flowers development, Effects of salt stress on citrus cultures.
Dani Zamir

Prof. Dani Zamir

Emeritus
Tel: +972-(0)8-9489092/250 | Fax: +972-(0)8-9489943
dani.zamir@mail.huji.ac.il
Building A
Identification of genes and mechanisms for crop productivity.
Elisha Tel-Or

Prof. Elisha Tel-Or

Emeritus
Tel: +972-(0)8-9489262 | Fax: +972-(0)8-9468785
elisha.telor@mail.huji.ac.il
Building A
Plant Responses to Environmental Abiotic Stresses; Phytoremediation of industrial sludges by the Nymphae is being developed for polluted sludge in Haifa Bay.
Amnon Schwartz

Prof. Amnon Schwartz

Emeritus
Tel: +972-(0)8-9489917 | Fax: +972-(0)8-9489069 | Cell: +972-(0)52-8634452
amnon.schwartz@mail.huji.ac.il
Building A

Plant water relations, Plant gas exchange, Irrigation scheduling of orchards and vineyards based on physiological parameters.

Baruch Rubin

Prof. Baruch Rubin

Emeritus
Tel: +972-(0)8-9489248 | Fax: +972-(0)8-9362083 | Cell: +972-(0)54-8820054
rubin@mail.huji.ac.il
Building A
Weed biology and management; herbicide physiology and action in crops, weeds and environment; Mechanisms of herbicide-resistance in weeds.
Joseph Riov

Prof. Joseph Riov

Emeritus
Tel: +972-(0)54-8820686 l Fax: +972-(0)8-9489544
joseph.riov@mail.huji.ac.il
Kennedy Leigh A, room 220
Mechanisms of controlling adventitious root formation, with an emphasis on auxin activity and metabolism. Genetics of forest trees.
Haim D. Rabinowitch

Prof. Haim D. Rabinowitch

Emeritus
Tel: +972-(0)8-9489244 | Fax: +972-(0)8-9462384
haim.rabinowitch@mail.huji.ac.il
Kennedy Leigh A

Vegetable physiology, breeding & seed production, esp. tomatoes, alliums, and potatoes.